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HAV does not cause chronic infection and should not be in the differential diagnosis of chronic hepatitis

demonstrated that Tom20 or Bax knockout effectively blocks ROS-induced pyroptosis, while antioxidant treatment significantly reduces Tom20 oxidation, Bax mitochondrial recruitment, and GSDME cleavage, further confirming that ROS serves as the central regulator of this signaling pathway (47)

PKG: Protein kinase-G POD: Peroxidase PLP: Pyridoxal 5-phosphate ROS: Reactive oxygen species SAG: Senescence-activated promoter SAM: S-adenosyl-methionine SOD: Superoxide dismutase SSA: Succinic semi-aldehyde SSADH: Succinic semi-aldehyde dehydrogenase SSR: Succinic semi-aldehyde reductase References Abd Elbar OH, Elkelish A, Niedbaa G et al (2021) Protective effect of -aminobutyric acid against chilling stress during reproductive stage in tomato plants through modulation of sugar metabolism, chloroplast integrity, and antioxidative defense systems

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